{"id":8860674490656,"title":"SAMe · 200 mg","handle":"same-200-mg","description":"\u003cp\u003e\u003c\/p\u003e\u003cul\u003e\n\n\u003cli\u003eRelieves osteoarthritis pain\u003c\/li\u003e\n\n\u003cli\u003e Key factor in several biological pathways including methylation reactions, glutathione formation, and glutathione S-transferase activity\u003c\/li\u003e\n\n\u003cli\u003e Enteric coating protects SAMe degradation caused by stomach acid, allowing for significantly improved intestinal absorption.\u003c\/li\u003e\n\n\u003cli\u003e 200 mg SAMe per tablet for flexible dose titration\u003c\/li\u003e\n\n\u003cli\u003e SAMe is produced through a natural fermentation process that produces higher active ingredients than synthetic variations.\u003c\/li\u003e\n\n\u003cli\u003e Suitable for vegetarians\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\n [TABS]\n\u003ch5\u003e Description\u003cbr\u003e\n\n\u003c\/h5\u003e\n\u003cp\u003e S-Adenosyl-L-Methionine (SAMe) has several essential physiological functions and is the common thread between three key metabolic pathways. Well recognized as a unique methyl donor for over 100 biological reactions, including DNA methylation. It also links methylation to the synthesis of polyamines (necessary for cell survival and growth) and transsulfuration, which is responsible for the production of cysteine, the limiting factor in glutathione synthesis. Its unique positioning within these crossed pathways explains its role as regulator of redox status, cellular metabolism, proliferation and apoptosis.\u003cbr\u003e\u003cbr\u003e It has been clinically proven to relieve a number of conditions, including osteoarthritis, fibromyalgia, neurodegenerative diseases, depression and liver disease. For patients with major depressive disorder, SAMe has been shown to be effective not only compared to standard antidepressants, but also for non-responders to selective serotonin reuptake inhibitors (SSRIs). It has also been shown to reduce the incidence of sexual dysfunction that commonly accompanies SSRI\/SNRI treatment. SAMe has also shown efficacy for osteoarthritis comparable to that of NSAIDs, including celecoxib. More importantly, this is likely due to an increase in cartilage formation, glutathione production, DNA methylation, and gene expression that contribute to its effectiveness, a stark contrast to pharmaceutical painkillers. . Research also suggests benefit for neurodegenerative diseases and potentially for improving endothelial function.\u003c\/p\u003e\n\u003ch5\u003e Dosage\u003cbr\u003e\n\n\u003c\/h5\u003e\n\u003cp\u003e\u003cmeta charset=\"UTF-8\"\u003e \u003cstrong\u003eAdults:\u003c\/strong\u003e SAMe should always be taken on an empty stomach and for at least 2 weeks, after which the effects should be observed.\u003cbr data-mce-fragment=\"1\"\u003e \u003cstrong\u003eFor mood balance:\u003c\/strong\u003e 1 to 4 tablets 2 times daily or as directed by a healthcare professional. Consult a healthcare professional for use beyond 6 weeks.\u003cbr data-mce-fragment=\"1\"\u003e \u003cstrong\u003eFor osteoarthritis pain:\u003c\/strong\u003e 2 tablets 3 times a day or as recommended by a healthcare professional. Do not exceed 6 tablets per day. Consult a healthcare professional for use beyond 12 weeks.\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003e Nutritional information\u003cbr\u003e\n\n\u003c\/h5\u003e\n\u003cp\u003e \u003cb\u003eMedicinal ingredients per tablet:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e S-Adenosyl-L-Methionine (SAMe) 200 mg\u003c\/p\u003e\n \u003cb style=\"font-size: 0.875rem;\"\u003eNonmedicinal ingredients:\u003c\/b\u003e Microcrystalline cellulose, coating (talc, glycerin, arginine, vegetable magnesium stearate (lubricant), silica, sodium alginate), stearic acid, vegetable magnesium stearate (lubricant), magnesium hydroxide, silica, calcium oxide .","published_at":"2023-11-18T07:50:54-05:00","created_at":"2023-11-18T07:50:57-05:00","vendor":"Bioclinic Naturals","type":"","tags":["Comprimés","Douleur \/ Inflammation","Humeur","Sans gluten","Sans OGM","Sans produits laitiers","SYSTÈME NERVEUX","SYSTÈME OSTÉO-MUSCULAIRE \u0026 TÉGUMENTAIRE"],"price":2029,"price_min":2029,"price_max":2029,"available":true,"price_varies":false,"compare_at_price":2899,"compare_at_price_min":2899,"compare_at_price_max":2899,"compare_at_price_varies":false,"variants":[{"id":47165802742048,"title":"30 Tablets","option1":"30 Tablets","option2":null,"option3":null,"sku":"same-bioclinic-naturals-30c","requires_shipping":true,"taxable":true,"featured_image":{"id":43421246521632,"product_id":8860674490656,"position":1,"created_at":"2023-11-18T07:50:57-05:00","updated_at":"2023-11-18T07:50:57-05:00","alt":null,"width":600,"height":600,"src":"\/\/unytiipro.com\/cdn\/shop\/products\/t78uhkkxptxkzns3vpqv_7c07bfaf-3c4f-4ff5-86cb-6f04b051541f.jpg?v=1700311857","variant_ids":[47165802742048]},"available":true,"name":"SAMe · 200 mg - 30 Tablets","public_title":"30 Tablets","options":["30 Tablets"],"price":2029,"weight":0,"compare_at_price":2899,"inventory_management":"shopify","barcode":"629022092468","featured_media":{"alt":null,"id":35827488817440,"position":1,"preview_image":{"aspect_ratio":1.0,"height":600,"width":600,"src":"\/\/unytiipro.com\/cdn\/shop\/products\/t78uhkkxptxkzns3vpqv_7c07bfaf-3c4f-4ff5-86cb-6f04b051541f.jpg?v=1700311857"}},"requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/unytiipro.com\/cdn\/shop\/products\/t78uhkkxptxkzns3vpqv_7c07bfaf-3c4f-4ff5-86cb-6f04b051541f.jpg?v=1700311857","\/\/unytiipro.com\/cdn\/shop\/products\/same-bioclinic-naturals-30c.png?v=1700311857"],"featured_image":"\/\/unytiipro.com\/cdn\/shop\/products\/t78uhkkxptxkzns3vpqv_7c07bfaf-3c4f-4ff5-86cb-6f04b051541f.jpg?v=1700311857","options":["Format"],"media":[{"alt":null,"id":35827488817440,"position":1,"preview_image":{"aspect_ratio":1.0,"height":600,"width":600,"src":"\/\/unytiipro.com\/cdn\/shop\/products\/t78uhkkxptxkzns3vpqv_7c07bfaf-3c4f-4ff5-86cb-6f04b051541f.jpg?v=1700311857"},"aspect_ratio":1.0,"height":600,"media_type":"image","src":"\/\/unytiipro.com\/cdn\/shop\/products\/t78uhkkxptxkzns3vpqv_7c07bfaf-3c4f-4ff5-86cb-6f04b051541f.jpg?v=1700311857","width":600},{"alt":null,"id":35827488850208,"position":2,"preview_image":{"aspect_ratio":2.147,"height":347,"width":745,"src":"\/\/unytiipro.com\/cdn\/shop\/products\/same-bioclinic-naturals-30c.png?v=1700311857"},"aspect_ratio":2.147,"height":347,"media_type":"image","src":"\/\/unytiipro.com\/cdn\/shop\/products\/same-bioclinic-naturals-30c.png?v=1700311857","width":745}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003cp\u003e\u003c\/p\u003e\u003cul\u003e\n\n\u003cli\u003eRelieves osteoarthritis pain\u003c\/li\u003e\n\n\u003cli\u003e Key factor in several biological pathways including methylation reactions, glutathione formation, and glutathione S-transferase activity\u003c\/li\u003e\n\n\u003cli\u003e Enteric coating protects SAMe degradation caused by stomach acid, allowing for significantly improved intestinal absorption.\u003c\/li\u003e\n\n\u003cli\u003e 200 mg SAMe per tablet for flexible dose titration\u003c\/li\u003e\n\n\u003cli\u003e SAMe is produced through a natural fermentation process that produces higher active ingredients than synthetic variations.\u003c\/li\u003e\n\n\u003cli\u003e Suitable for vegetarians\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\n [TABS]\n\u003ch5\u003e Description\u003cbr\u003e\n\n\u003c\/h5\u003e\n\u003cp\u003e S-Adenosyl-L-Methionine (SAMe) has several essential physiological functions and is the common thread between three key metabolic pathways. Well recognized as a unique methyl donor for over 100 biological reactions, including DNA methylation. It also links methylation to the synthesis of polyamines (necessary for cell survival and growth) and transsulfuration, which is responsible for the production of cysteine, the limiting factor in glutathione synthesis. Its unique positioning within these crossed pathways explains its role as regulator of redox status, cellular metabolism, proliferation and apoptosis.\u003cbr\u003e\u003cbr\u003e It has been clinically proven to relieve a number of conditions, including osteoarthritis, fibromyalgia, neurodegenerative diseases, depression and liver disease. For patients with major depressive disorder, SAMe has been shown to be effective not only compared to standard antidepressants, but also for non-responders to selective serotonin reuptake inhibitors (SSRIs). It has also been shown to reduce the incidence of sexual dysfunction that commonly accompanies SSRI\/SNRI treatment. SAMe has also shown efficacy for osteoarthritis comparable to that of NSAIDs, including celecoxib. More importantly, this is likely due to an increase in cartilage formation, glutathione production, DNA methylation, and gene expression that contribute to its effectiveness, a stark contrast to pharmaceutical painkillers. . Research also suggests benefit for neurodegenerative diseases and potentially for improving endothelial function.\u003c\/p\u003e\n\u003ch5\u003e Dosage\u003cbr\u003e\n\n\u003c\/h5\u003e\n\u003cp\u003e\u003cmeta charset=\"UTF-8\"\u003e \u003cstrong\u003eAdults:\u003c\/strong\u003e SAMe should always be taken on an empty stomach and for at least 2 weeks, after which the effects should be observed.\u003cbr data-mce-fragment=\"1\"\u003e \u003cstrong\u003eFor mood balance:\u003c\/strong\u003e 1 to 4 tablets 2 times daily or as directed by a healthcare professional. Consult a healthcare professional for use beyond 6 weeks.\u003cbr data-mce-fragment=\"1\"\u003e \u003cstrong\u003eFor osteoarthritis pain:\u003c\/strong\u003e 2 tablets 3 times a day or as recommended by a healthcare professional. Do not exceed 6 tablets per day. Consult a healthcare professional for use beyond 12 weeks.\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003e Nutritional information\u003cbr\u003e\n\n\u003c\/h5\u003e\n\u003cp\u003e \u003cb\u003eMedicinal ingredients per tablet:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e S-Adenosyl-L-Methionine (SAMe) 200 mg\u003c\/p\u003e\n \u003cb style=\"font-size: 0.875rem;\"\u003eNonmedicinal ingredients:\u003c\/b\u003e Microcrystalline cellulose, coating (talc, glycerin, arginine, vegetable magnesium stearate (lubricant), silica, sodium alginate), stearic acid, vegetable magnesium stearate (lubricant), magnesium hydroxide, silica, calcium oxide ."}