Cortisolv

Contributes to the proper regulation of cortisol levels, an indicator of stress. Temporarily alleviates perceived symptoms of stress. Helps relieve stress-related symptoms such as fatigue, insomnia, and restlessness. Cortisolv is a multifunctional herbal supplement that offers significant and complementary benefits for those seeking help to cope with daily stress. It contains a unique combination of clinically tested and patented ingredients, including Relora®, Sensoril®, and Suntheanine®, as well as extracts of banaba leaf and maral. Together, these herbs help the overworked body and mind work toward their normal state of balance and resolve many of the biochemical changes that occur as a result of repeated and frequent exposure to stressors and cortisol. Relora® is a patented and proprietary blend of Magnolia officinalis and Phellodendron amurense bark extracts standardized to honokiol and berberine, respectively. These herbs have a history of traditional use in the treatment of stress and occasional feelings of anxiety. In modern times, they and their active ingredients (honokiol and berberine) are used to promote relaxation and reduce the perception of stress and stress-related eating. Rodent stress studies demonstrate a reduction in induced feelings of anxiety. Human studies demonstrate positive changes in DHEA (dehydroepiandrosterone) and cortisol levels, less weight gain (compared to controls), and reductions in perceived stress and transient feelings of anxiety in subjects taking Relora (500 mg to 750 mg for four to six weeks). For example, cortisol exposure and psychological mood states were studied in 56 subjects (35 men and women) taking Relora (250 mg twice daily) or placebo. After four weeks of supplementation, salivary cortisol exposure was significantly lower (−18%) in the Relora group compared to placebo. The Relora group also had significantly better mood state parameters, including lower indices of overall stress (-11%), tension (-13%), anger (-42%), occasional fatigue (-31%), and confusion (-27%), and higher indices of overall mood state (+11%) and vigor (+18%). Sensoril® is an optimized extract of ashwagandha (Withania somnifera) root and leaf that represents a major advancement in ashwagandha preparations. Sensoril's proprietary and patented extraction process produces very high and potent levels of ashwagandha's bioactive constituents that combat stress and improve cognition. Indeed, Sensoril is standardized to a minimum of 10% glycowithanolides. Sensoril's excellent safety record is one of the most comprehensive of any ashwagandha ingredient sold. Ashwagandha has been revered as an adaptogen for thousands of years. It is used to balance, energize, and revitalize the body and for its value as a cognitive enhancer. Sensoril has multiple health benefits, and its superior efficacy has been demonstrated in randomized, double-blind, placebo-controlled human clinical trials. The results of these trials revealed that Sensoril, taken at doses of 500 to 1000 mg/d, supported healthy cortisol and DHEA levels; improved working memory, reaction time, and cognitive ability; improved auditory-verbal working memory; ameliorated negative changes in cardiovascular parameters associated with mental stress; and improved endothelial function and glucose and lipid metabolism. Suntheanine® is a pure form of L-theanine that is produced via a patented fermentation process, resulting in 100% pure L-isomer-theanine. Clinical research suggests that 50 to 200 mg/d of Suntheanine naturally stimulates activity in the brain called alpha waves, which are associated with a relaxed but alert mental state. L-theanine has had significant anti-stress effects in laboratory animals subjected to psychosocial stress. In humans, similar results have been observed in which L-theanine helped the body resist the biochemical changes associated with stress. given to boys aged 8 to 12 years, improved some aspects of sleep quality, including significantly higher percentage of sleep and sleep efficiency scores, and a non-significant trend toward decreased activity during sleep. Banaba leaf (Lagerstroemia speciosa) has a long history of use in traditional medicine, particularly in Southeast Asia, as a glucose modulator. More recently, animal and human research on banaba leaf and its actives, including corosolic acid, suggests multiple mechanisms that influence glucose and lipid metabolism. In addition, corosolic acid inhibits the enzyme that facilitates the conversion of cortisone to cortisol. Maral extract (Rhaponticum carthamoides) has been widely used in Siberian traditional medicine, primarily to treat overwork and joint weakness resulting from illness. It has also been historically used as a stimulant and remedy to support male sexual function. The main bioactive constituents of this plant are ecdysteroids, flavonoids, and phenolic acids. A review of Maral Chemistry and Pharmacology calls it an "adaptogenic herbal remedy."