I 3 C - Indole-3-Carbinol

Indicated for proper estrogen metabolism and symptomatic control in estrogen-dominated health conditions. Shown to support healthy cellular differentiation of breast and cervical tissues. Proper estrogen metabolism is a crucial factor in maintaining the ongoing balance of hormones in the body and optimizing health outcomes. The initial estrogen detoxification step in the liver creates the metabolites 2-hydroxyestrone (2-OHE1), 4-hydroxyestrone (4-OHE1), and 16-hydroxyestrone (16-OHE1). While there are many steps in estrogen elimination, this first step is critical because each metabolite has unique actions in the body. The ratio of these compounds has immense implications for health. Indole-3-carbinol (I-3-C) is naturally found in cruciferous vegetables such as broccoli and cauliflower and is well known for its ability to support healthy estrogen metabolism. I-3-C upregulates the production of 2-OHE1, the protective form of estrogen that acts as an estrogen antagonist. 16-OHE1, on the other hand, has potent estrogenic and proliferative effects that oppose the action of 2-OHE1. Research has repeatedly shown that a higher ratio of 2-OHE1 to 16-OHE1 is protective against disease and desirable for improving symptoms in estrogen-dominant conditions. I-3-C improves this estrogen metabolite ratio. Numerous trials have shown that this positive change in estrogen metabolites, following I-3-C supplementation, is beneficial for health outcomes. For example, I-3-C has been shown to improve outcomes in women with cervical disease, with a dose-dependent response for estrogen ratios and regression of CIN severity. Animal studies have also shown that I-3-C can prevent unhealthy cellular differentiation in breast tissue. Not only does I-3-C promote a positive estrogen-metabolite ratio, but it also influences the expression of several genes, such as the tumor suppressor gene p53 and BRCA1, which collectively support the healthy differentiation of hormone-sensitive tissues. I-3-C is naturally metabolized in the body to provide multiple active compounds, including the predominant metabolite diindolylmethane (D-I-M). While there is some debate as to whether D-I-M or I-3-C is more beneficial as a health supplement, each compound has its advantages. D-I-M is the primary metabolite of I-3-C, but it is not the only metabolite. I-3-C provides the body with all active metabolites and remains a well-researched and effective treatment for the proper regulation of estrogen in the body. I-3-C from Cyto-Matrix contains 200 mg of pure indole-3-carbinol in each vegetarian capsule, with 120 vegetarian capsules per bottle for targeted and continuous hormonal support.