NEM 500mg

Natural Eggshell Membrane (NEM®) is clinically proven to reduce joint pain and stiffness due to osteoarthritis. It is clinically proven to reduce pain and stiffness resulting from moderate-intensity aerobic exercise. Pain, stiffness, and flexibility improve within days of use. NEM provides numerous joint nutrients, including glucosamine, chondroitin, and type I collagen. One NEM vegetarian capsule daily is the clinically proven dose. Numerous clinical trials have shown that NEM reduces joint pain and stiffness associated with osteoarthritis, as well as joint pain and stiffness caused by moderate-intensity aerobic exercise. NEM is composed of eggshell membranes (without eggshell), a natural source of glycosaminoglycans found in cartilage, including dermatan sulfate and chondroitin sulfate, hexosamines such as glucosamine, as well as hyaluronic acid and type I collagen. In vitro and in vivo trials indicate that NEM has multiple mechanisms of action, including the inhibition of several pro-inflammatory cytokines associated with joint inflammation, such as interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α). In a randomized, double-blind, placebo-controlled trial, NEM was shown to rapidly reduce pain, stiffness, and discomfort following exercise in healthy postmenopausal women. It has also been shown to reduce urinary levels of C-terminal cross-linked telopeptide of type II collagen (CTX-II), a biomarker of cartilage breakdown, in both healthy individuals and those with joint disease. Additionally, controlled clinical trials have shown reduced joint pain and stiffness in individuals with knee osteoarthritis within 10 days of using NEM. Open-label trials have shown persistent improvements in pain and flexibility for multiple joint and connective tissue disorders within one week.