NMN

Provides 150 mg of nicotinamide mononucleotide (NMN) per serving, which has been shown in clinical trials to increase blood NAD+ levels. NMN is the immediate precursor to NAD+ and bridges the age-related decline in NAD+ levels. NAD+ is an essential coenzyme for many pathways related to energy production, mitochondrial health, and DNA repair, and its decline is strongly associated with aging. Vegetarian capsules with clinically established dosage NMN is a bioavailable precursor to nicotinamide adenine dinucleotide (NAD+), a key coenzyme required for over 500 enzymatic reactions. Because many of these enzymatic reactions are related to cellular metabolism, aging, inflammation, circadian rhythm, mitochondrial respiration, glycolysis, and DNA repair, NAD+ is considered essential for human health and longevity. NAD+ is also required for the expression of sirtuins, enzymes with numerous cellular regulatory effects particularly important for inflammation, DNA repair, and energy metabolism. Considerable research shows that aging results in decreased NAD+ and sirtuin expression, leading to impaired mitochondrial function and biogenesis and increased oxidative damage, drivers of the aging process itself as well as many diseases associated with aging, including cardiovascular and metabolic diseases. Controlled clinical trials have demonstrated multiple benefits of NMN supplementation, including improved insulin sensitivity and signaling in women with impaired glucose metabolism, as well as aerobic fitness in healthy runners, reduced sleepiness, and improved sitting posture in older adults.6-8 To illustrate its potential to affect aging pathways by restoring NAD+ levels, supplementing with NMN for 12 weeks found a trend toward reduced arterial stiffness, an independent aging-related risk factor for cardiovascular and metabolic diseases.